Home | MiZ Company Limited

We can provide any of administration routes, namely intravenous drip, intravenous infusion, oral ingestion, and gas inhalation of molecular hydrogen desired by a researcher or developer.

Topics

Archive

October 8, 2018: A proposal titled “Radical curatives will play a key role in the universal health care” by MiZ Company Limited and Keio University was published on the web page of Science, an academic journal with international authority.
http://science.sciencemag.org/content/361/6404/eaat9644/tab-e-letters
In this article, we demonstrated that for the global health management efforts, we should aim for fundamental therapy rather than developing individual therapeutic agents.
October 8, 2018: A proposal titled “Who will be suffering from losing the Alzheimer’s gamble” by MiZ Company Limited and Keio University was published on the web page of Science, an academic journal with international authority.
http://science.sciencemag.org/content/361/6405/838/tab-e-letters
In this article, we demonstrated that in order to solve the stagnant Alzheimer's disease study, we should try safe therapeutic development early.
September 26, 2018: A document titled “Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression" is disclosed in the journal of Scientific Reports (online offshoot magazine of the British scientific journal Nature), as results of collaborative research with our company, National Research Institute for Child Health and Development, Osaka University, and Toyama University. In this document, we have reported that the super-saturated hydrogen water (7 ppm) markedly protected the ischemia-reperfusion injury using transplantation model of a mouse fatty liver.
August 27, 2018: In the 8th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Bell Classic Tokyo on August 23 and 24, 2018, as a result of collaboration study between MiZ Co., Ltd. and National Defense Medical College, a research report was presented using MiZ’s hydrogen gas inhaler, titled “Application of molecular hydrogen to blast-induced traumatic brain injury”. In addition, the result of this research was reported as the scientific journal (https://www.ncbi.nlm.nih.gov/pubmed/30053086)
August 27, 2018: In the 8th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Bell Classic Tokyo on August 23 and 24, 2018, as a result of collaboration study between MiZ Co., Ltd. and Osaka University, a research report was presented using MiZ’s super-saturated hydrogen water, titled “Hydrogen-rich saline regulates intestinal barrier dysfunction, dysbiosis, and bacterial translocation in a murine model of sepsis”. In addition, the result of this research was reported as the scientific journal (https://www.ncbi.nlm.nih.gov/pubmed/29293174)
August 27, 2018: In the 8th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Bell Classic Tokyo on August 23 and 24, 2018, as a result of collaboration study between MiZ Co., Ltd. and Nagoya University, a research report was presented using MiZ’s super-saturated hydrogen water, titled “Molecular hydrogen induces mitochondrial unfolded response (mtUPR)”.
July 11, 2018: "Method of obtaining hydrogen concentration in hydrogen-containing liquid and generator for hydrogen-containing liquid " was granted a patent in Taiwan (PAT No:　I629480).
July 5, 2018: "APPARATUS AND METHOD FOR PRODUCING HYDROGEN-CONTAINING LIQUID" was granted a patent in India (PAT No:298525).
June 7, 2018: "APPARATUS, METHOD and KIT FOR PRODUCING HYDROGEN-CONTAINING LIQUID" was granted a patent in Korea (PAT No: JP10-186348(B)).
June 6, 2018: "APPARATUS AND METHOD FOR PRODUCING HYDROGEN-CONTAINING LIQUID" was granted a patent in Japan (PAT No: JP6340033(B)).
April 16, 2018: In the 38^th Annual Meeting of International Society for Heart and Lung Transplantation held at Nice in France on April 11 to 14, 2018, as a result of collaboration study between MiZ Co., Ltd. and Kyoto University, a research report was presented, using MiZ's super-saturated hydrogen water, titled “Protective effect of hydrogen-rich preservation solution during cold ischemia in rat lung transplantation”.
March 26, 2018: A research study by our Company on problems about explosive hydrogen concentration of hydrogen gas inhaler was disclosed in the Direct Marketing News, a newspaper of direct marketing, published on March 22, 2018.
February 19, 2018: “High-Concentration Hydrogen Gas Supply Device for Living Bodies” was granted a patent in Hong Kong (PAT No: HK1204346).
February 15, 2018: A document titled “Hydrogen-rich saline regulates intestinal barrier dysfunction, dysbiosis and bacterial translocation in a murine model of sepsis" is disclosed in the journal of Shock (international scientific journal in the area of emergency medicine), as results of our company and Osaka University Graduate of Medicine. In this document, we have reported that the super-saturated hydrogen water (7 ppm) markedly improved survival rate in a murine model of sepsis, via the regulation of intestinal barrier dysfunction, dysbiosis and bacterial translocation.
December 15, 2017: A research study by our Company on problems about hydrogen supplement was disclosed in the Direct Marketing News, a newspaper of direct marketing, published on December 14, 2017.
November 9, 2017: “Method and device for producing a hydrogen containing fluid applicable to a living organism” was granted a patent in China (PAT No: ZL201580000856. 1).
November 6, 2017: “Selective hydrogen adding equipment for living organism applicable fluid” was granted a patent in Indonesia (PAT No: P000044303).
November 2, 2017: In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd., Clinic C4, National Institute for Child Health and Development and Osaka University Graduate School of Medicine, Shin-ichi HIRANO, Managing Director of MiZ Co. Ltd., presented a research report using hydrogen gas inhalers titled “Hyperbaric hydrogen gas inhalation attenuates bone marrow damage in cancer patients induced by radiotherapy”.
November 2, 2017: In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden Palace on October 29 and 30, 2017, Ryosuke KUROKAWA, General Manager of Research and Development of MiZ Co., Ltd., presented a study titled “Explosive concentration of hydrogen gas and safety of hydrogen gas inhaler”.
November 2, 2017: In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden Palace on October 29 and 30, 2017, Tomoki SEO, Director of MiZ Co., Ltd., presented a study titled “Analysis result of hydrogen supplement sold at a market”.
November 2, 2017: In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and Juntendo University, a research report was presented using MiZ’s super-saturated hydrogen water, titled “A randomized double-blind, placebo-controlled multi-center trial of molecular hydrogen water for Parkinson’s disease”.
November 2, 2017: In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and Chubu University, a research report was presented, using MiZ’s super-saturated hydrogen water, titled “Molecular hydrogen alters gene expression via epigenetic mechanism and activates mitochondrial unfolded protein response for the protection against stress-induced damage”.
November 2, 2017: In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and Juntendo University, a research report was presented, using MiZ’s super-saturated hydrogen water, titled “Hydrogen-rich pure water prevents cigarette smoked-induced pulmonary emphysema in SMP30 knockout mice”.
November 2, 2017: In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and Kyoto University, a research report was presented, using MiZ’s non-destructive adding apparatus, titled “Protective effect of hydrogen-rich solution during lung cold preservation in rats”.
November 2, 2017: In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and Kyoto University, a research report was presented, using MiZ’s, non-destructive adding apparatus, titled “Hydrogen perfusion after cold storage; A new, simple, and non-invasive graft conditioning for ameliorating hepatic ischemia/reperfusion injury”.
November 2, 2017: In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and National Defense Medical College, a research report was presented, using MiZ ‘s non-destructive hydrogen adding apparatus, titled “Combination therapy of intravenous hydrogen saturated solution and intracisternal magnesium sulfate infusion to rat subarachnoid hemorrhage model”.
August 24, 2017: An interview document titled as “Agency sales of hydrogen gas inhaler sales business is in good demand” from Shin-ichi Hirano, Managing Director, Research and Development of MiZ Company Limited was disclosed in the Nippon Distribution Industry Newspaper published on August 24, 2017.
August 23, 2017: “Method of adding hydrogen to a fluid that is applicable to living organism” was granted a patent in Europe (PAT No: 3026025).
August 3, 2017: An interview document titled as “Future prospect in hydrogen gas area” from Shin-ichi Hirano, Managing Director, Research and Development of MiZ Company Limited was disclosed in the Direct Marketing News, a specialty paper of direct marketing in Japan, published on August 8, 2017.
August 1, 2017: “Apparatus for supplying high-concentration hydrogen gas for living organism” was granted a patent in USA (PAT No: 9717877).
Jury 21, 2017: “Apparatus for generating hydrogen gas” was granted a patent in Taiwan (PAT No: I592518).
July 7, 2017: “Method for producing hydrogen water” (PAT No: 6169762) , “Nasal cannula” (PAT No: 6169771) , and “Method for producing hydrogen-containing liquid” (PAT No: 6170605) were granted patents in Japan.
June 5, 2017: We renewed our home page on "Applied Technologies" in association with our development of high-concentration hydrogen water generator directly connected with tap water pipes.
May 26, 2017: “Method of obtaining hydrogen concentration in hydrogen-containing liquid and generator for hydrogen-containing liquid” was granted a patent in Japan (PAT NO: 6148759).
May 4, 2017: An article on Media Workshop presented by Molecular Hydrogen Clinical Engineering Association (Incorporated Corporation) appeared on “News on Sales” (industry newspaper for visiting sales) in its May 4, 2017 publication.
April 18, 2017: Shin-ichi Hirano, Managing Director, Research and Development of MiZ Company Limited, made a presentation titled as “Current situation and future prospect on medical research on molecular hydrogen” at the Media Workshop presented by Molecular Hydrogen Clinical Engineering Association (Incorporated Corporation) held at Tokyo Station Conference on April 13, 2017.
December 27, 2016: On December 15, 2016, National Life Center (Independent Administrative Agency) opened the product test result titled as “Hydrogen water for drinking or hydrogen water produced in bottles or by inhalers has no official definition etc. and there are different hydrogen concentration on these products.”
December 15, 2016: We will have an exhibition in The 50th Annual Meeting of the Japanese Society for Clinical Renal Transplantation on February 15 to 17, 2017 at Kobe Convention Center, in order to introduce the representative technologies of our company.
November 23, 2016: "Producing method for living organism-applicable hydrogen-contained fluid and producing apparatus for the same" was granted a patent in Europe (PAT NO: 2 407 141).
November 11, 2016: We will have an exhibition in the Direct Marketing Fair 2016 held at Tokyo Big Sight on December 6 and 7, 2016, in order to introduce the representative technologies of our company, such as non-destructive hydrogen adding devices, super-saturated hydrogen water, hydrogen gas inhaler, and dissolved hydrogen concentration measuring reagent.
November 11, 2016: Research of "Perfusion of hydrogen-containing solution via portal vein after preservation of transplanted liver alleviates the ischemia and reperfusion injury" employing the non-destructive hydrogen adding devices will be presented at The 43th Annual Meeting of Japan Society for Organ Preservation and Biology 2016 held on November 26 and 27, 2016, as a result of collaborative research by our company and Kyoto University.
September 13, 2016: We will have an exhibition in The 22nd Annual Meeting of the Japanese Society for Peritoneal Dialysis held at International Conventioncenter PAMIR of Sapporo Prince Hotel on September 24 to 25, 2016, in order to introduce the representative technologies of our company.
September 7, 2016: "Apparatus for supplying high-concentration hydrogen gas for living organism" was granted a patent in Europe (PAT NO: 2 857 555).
August 29, 2016: "Method and device for producing a hydrogen containing fluid applicable to a living organism" was granted a patent in Korea (PAT NO: 10-165393).
June 3, 2016: Research of ‘‘Proposal of a new therapeutic strategy intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate” using the nondestructive hydrogen adding apparatus was presented in The 6th Annual Meeting of Japan Molecular Hydrogen Biomedical Society at The Wakupia Yokohama on May 29 2016, as a result of collaborative research by our company and National Defense Medical College.
June 3, 2016: Research of ‘‘Molecular hydrogen; a potential relaxing factor of peripheral blood vessels” using the super saturated hydrogen water and nondestructive hydrogen adding apparatus was presented in The 6th Annual Meeting of Japan Molecular Hydrogen Biomedical Society at The Wakupia Yokohama on May 28 2016, as a result of collaborative research by our company and Huis Ten Bosch Satellite H2 Clinic Hakata.
June 3, 2016: Research of ‘‘Combination therapy of intravenous hydrogen saturated solution and intra-cisternal magnesium sulfate infusion to rat subarachnoid hemorrhage model” using the nondestructive hydrogen adding apparatus was presented in The 6th Annual Meeting of Japan Molecular Hydrogen Biomedical Society at The Wakupia Yokohama on May 28 2016, as a result of collaborative research by our company and National Defense Medical College.
June 3, 2016: Research of ‘‘A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics” using the super saturated hydrogen water was presented in The 6th Annual Meeting of Japan Molecular Hydrogen Biomedical Society at The Wakupia Yokohama on May 28 2016, as a result of collaborative research by our company and Juntendo University.
May 18, 2016: We will have an exhibition in The 75th Annual Meeting of the Japanese Cancer Association held at Pacifico Yokohama on October 6 to 8, 2016, in order to introduce the representative technologies of our company.
May 18, 2016: We will have an exhibition in The 38th Congress of Japan Respiratory Therapy Medical Association held at Nagoya Congress Center on Jury 16 and 17, 2016, in order to introduce the representative technologies of our company.
May 18, 2016: We will have an exhibition in The 21th Congress of Japan Society of Palliative Medicine held at Kyoto International Conference Center on June 17 and 18, 2016, in order to introduce the representative technologies of our company.
May 6, 2016: Research of ‘‘Effects of hydrogen saline pretreatment on mouse fatty liver ischemia-reperfusion injury ”employing the super saturated hydrogen saline will be presented held in The 6th Annual Meeting of Japan Molecular Hydrogen Biomedical Society at The Wakupia Yokohama on May 28, 2016, as a result of collaborative research by our company, National Institute of Child health and Development, and Toyama University.
May 6, 2016: Research of ‘‘Inhalation of hydrogen gas reduces anesthesia- and surgery-induced oxidative stress in dogs and cats” employing the hydrogen gas inhaler will be presented held in The 6th Annual Meeting of Japan Molecular Hydrogen Biomedical Society at the Wakupia Yokohama on May 28, 2016, as a result of collaborative research by our company and Animal Wellness Center.
April 28, 2016: We will have an exhibition in The 6th Annual Meeting of Japan Molecular Hydrogen Biomedical Society at the Wakupia Yokohama on May 28, 2016, in order to introduce the representative technologies of our company.
April 28, 2016: An interview document from our company’s corporate officer Shin-ichi Hirano was disclosed in the Direct Marketing News and Data, a specialty paper of direct marketing, published on April 28, 2016.
March 22, 2016: We have revised a page of “What is molecular hydrogen?” in our company’s web site, according to the development of hydrogen medicine.
March 22, 2016: We made the joint research agreement using molecular hydrogen with Central South University in China, for the animal study of hypoxic-ischemic encephalopathy.
February 2, 2016: We have established a home page of the hydrogen gas inhaler. Please refer to the web site as follows:
http://www.mhga.jp/product.html
January 26, 2016: We respectively made a joint research agreement using molecular hydrogen with Shanghai Jiaotong University, Soochow University, and with Huazhong University of Science and Technology in China, for the clinical studies of liver transplantation, post-stroke depression, and kidney transplantation.
January 7, 2016: A document titled "Interview about the future prospects of hydrogen water from our company’s corporate officer Shin-ichi Hirano" was disclosed in the Houhan News, a specialty paper of door-to-door sales industry, published on January 7, 2016.
January 7, 2016: A document titled "MiZ Co., Ltd. has published a paper in the Medical Gas Research, an US scientific journal" was disclosed in the Houhan News, a specialty paper of door-to-door sales industry, published on November 26, 2015.
October 28, 2015: We will have an exhibition in the Integrated Medicine Exhibition and Conference 2016 held at Tokyo Big Sight on January 26 and 27, 2016, in order to introduce the representative technologies of our company, such as nondestructive hydrogen adding apparatus, super-saturated hydrogen water, hydrogen gas inhaler, and dissolved hydrogen concentration measuring reagent.
October 28, 2015: A document titled “Convenient methods for ingestion of molecular hydrogen: drinking, injection, and inhalation’’ is disclosed in the journal of Medical Gas Research (international scientific online journal based in United States), as a results of our company’s research and development. In this document, we have reported the convenient and safe preparatory methods using devices for the ingestion of hydrogen and changes in the concentration of hydrogen.
→ http://www.medicalgasresearch.com/content/pdf/s13618-015-0034-2.pdf
October 28, 2015: It has been introduced in the following document that our company’s research reported in the journal of Bioscience, Biotechnology, and Biochemistry (English journal published in Japan Society for Bioscience, Biotechnology, and Agrochemistry) on 2005 was a pioneering work, because we explicitly proved that hydrogen-rich neutral water reduced oxidative stress in rats.
→ http://www.tandfonline.com/doi/pdf/10.1271/bbb.69.1985
→ http://www.medicalgasresearch.com/content/pdf/s13618-015-0035-1.pdf
September 3, 2015: We will have an exhibition in the Direct Marketing Fair 2015 held at Tokyo Big Sight on November 12 and 13, 2015, in order to introduce the representative technologies of our Company, such as nondestructive hydrogen adding apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and dissolved hydrogen concentration measuring reagent.
July 24, 2015: A document titled "Is the development of hydrogen for drug accelerated, since research of hydrogen has reached stage of clinical trials?" was disclosed in the magazine of Gas Review (No. 820, trade magazine of industrial gas) published on Jury 15, 2015, and the information of research and development of our company was introduced into the journal.
July 24, 2015: Research of "Preparation of hydrogen-rich atmosphere in on-tip devices for cell culture system" employing the dissolved hydrogen concentration measuring reagent will be presented at the Symposium of Medical and Biological Engineering 2015 held on September 25 and 26, 2015, as a result of collaborative research by our company, Shibaura Institute of Technology, and National Center for Child Health and Development.
June 19, 2015: We will have an exhibition in the Bio Japan 2015 held at Pacifico Yokohama on October 14 to 16, 2015, in order to introduce the representative technologies of our company, such as nondestructive hydrogen adding apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and dissolved hydrogen concentration measuring reagent.
June 19, 2015: A document titled “Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases” is disclosed in the journal of Molecular Medicine Reports (online scientific journal based in Italy and England), as a result of collaborative research by our company and Haradoi Hospital.
→ Link: http://www.biomedcentral.com/content/pdf/s12868-015-0165-3.pdf
June 19, 2015: Research of ‘‘Efficacy and its mechanism of hydrogen water on non-alcoholic steatohepatitis (NASH) in mice” employing the super saturated hydrogen water is presented at the 51th Annual Meeting of Japan Society of Hepatology held on March 21 and 22, 2015, as a result of collaborative research by our company and Toyama University.
May 11, 2015: A document titled “Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats” is disclosed in the journal of (international medical journal based in England), as a result of collaborative research by our company and National Defense Medical College.
→ Link: http://www.biomedcentral.com/content/pdf/s12868-015-0165-3.pdf
May 11, 2015: A document titled “Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats” is disclosed in the journal of Transplantation (Transplantation 2015; 99: 500-507, international journal in transplantation area), as a result of collaborative research by our company and National Center for Child Health and Development.
March 26, 2015: We will have an exhibition in the BIO tech Japan 2015 held at Tokyo Big Sight on May 13 to 15, 2015, in order to introduce the representative technologies of our company, such as nondestructive hydrogen adding apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and dissolved hydrogen concentration measuring reagent.
March 26, 2015: Research of ‘‘Molecular hydrogen’s effects on glycometabolism’’ employing the super-saturated hydrogen water was presented at the 5th Symposium of Medical Molecular Hydrogen held on March 21 and 22, 2015, as a result of collaborative research by our company and Nagoya University Graduate School of Medicine.
March 26, 2015: Research of ‘‘Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents ’’ employing the super-saturated hydrogen water was presented at the 5th Symposium of Medical Molecular Hydrogen held on March 21 and 22, 2015, as a result of collaborative research by our company and Chubu University.
March 26, 2015: Research of ‘‘Hydrogen supplementation of preservation solution improves viability of osteochondral grafts’’ employing the nondestructive hydrogen adding apparatus was presented at the 5th Symposium of Medical Molecular Hydrogen held on March 21 and 22, 2015, as a result of collaborative research by our company and Kitasato University Graduate School of Medical Science.
March 26, 2015: Research of ‘‘Molecular hydrogen: a potential mediator of endothelial function’’ employing the super-saturated hydrogen water and nondestructive hydrogen adding apparatus was presented at the 5th Symposium of Medical Molecular Hydrogen held on March 21 and 22, 2015, as a result of collaborative research by our company and Haradoi Hospital.
March 26, 2015: Research of ‘‘Changes in the hydrogen concentration in the various devices for ingestion of molecular hydrogen’’ employing the super-saturated hydrogen water, nondestructive hydrogen adding apparatus, hydrogen gas supply apparatus, and dissolved hydrogen concentration measuring reagent was presented at the 5th Symposium of Medical Molecular Hydrogen held on March 21 and 22, 2015, as a result of our company.
March 26, 2015: Research of ‘‘Molecular hydrogen reduces muscle degeneration in mdx mice’’ employing the super-saturated hydrogen water was presented at the 5th Symposium of Medical Molecular Hydrogen held on March 21 and 22, 2015, as a result of collaborative research by our company and Nagoya University Graduate School of Medicine.
March 26, 2015: Research of ‘‘Molecular hydrogen-saturated water attenuates and prevents chronic lung disorder in newborn rats’’ employing the super-saturated hydrogen water was presented at the 5th Symposium of Medical Molecular Hydrogen held on March 21 and 22, 2015, as a result of collaborative research by our company and Nagoya University Graduate School of Medicine.
March 26, 2015: Research of ‘‘Effect of the small intestine graft storage using hydrogen-containing storage method in small intestine transplant model of pig’’ employing the super-saturated hydrogen generating apparatus was presented at the 27th Japanese Society for Small Bowel Transplantation held on March 14, 2015, as a result of collaborative research by our company and National Center for Child Health and Development.
March 6, 2015: We will have an exhibition in the Tokyo Health Industry Show 2015 held at Tokyo Big Sight on March 11 to 13, 2015, in order to introduce the representative technologies of our company, such as nondestructive hydrogen adding apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and dissolved hydrogen concentration measuring reagent.
March 6, 2015: A document titled “Simultaneous oral and inhalation intake of molecular hydrogen additively suppresses signaling pathways in rodents’’ is disclosed in the journal of Molecular and Cellular Biochemistry (international scientific journal based in United States), as a result of collaborative research by our company and College of Life and Health Science, Chubu University.
→ Link: http://link.springer.com/article/10.1007/s11010-015-2353-y
February 13, 2015: We had an exhibition in the Regenerative Medicine Expo and Conference Japan 2015 held at Intex Osaka on February 4 to 6, 2015, in order to introduce the representative technologies of our company, such as nondestructive hydrogen adding apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and dissolved hydrogen concentration measuring reagent.
February 13, 2015: We had an exhibition in the Direct Marketing Fair 2014 held at Tokyo Big Sight on October 21 and 22, 2014, in order to introduce the representative technologies of our company, such as nondestructive hydrogen adding apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and dissolved hydrogen concentration measuring reagent.
January 14, 2015: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in China (PAT NO: ZL 201280035228.3).
December 3, 2014: A document titled “Hydrogen supplementation of preservation solution improves viability of osteochondral grafts’’ employing the nondestructive hydrogen adding apparatus is disclosed in the journal of The Scientific World Journal (online scientific journal based in Egypt and United States), as a result of collaborative research by our company and Kitasato University School of Medicine with School of Allied Health Science.
→ Link: http://www.hindawi.com/journals/tswj/2014/109876/abs/
December 1, 2014: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Israel (PAT NO: 229683).
November 18, 2014: "Hydrogen adding equipment for living organism applicable fluid" was granted a patent in US (PAT NO: 8,887,625 B2).
November 5, 2014: A document titled “Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function’’ employing the super saturated hydrogen water is disclosed in the journal of Vascular Health and Risk Management (British online scientific journal), as a result of collaborative research by our company and Haradoi Hospital.
→ Link: http://www.dovepress.com/articles.php?article_id=18794
October 21, 2014: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Singapore (PAT NO: 186786).
October 10, 2014: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Russia (PAT NO: 2530122).
September 16, 2014: New office building of our company was completed, and we moved to the following address. Address: 2-19-15 Ofuna Kamakura, Kanagawa 247-0056, Japan
August 20, 2014: A document titled ‘‘Physiological effects of combination therapy of intracisternal infusion of magnesium sulfate solution and intravenous injection of hydrogen-enriched fluid in the rat’’ employing the nondestructive hydrogen adding method is disclosed in The Journal of National Defense Medical College [39 (2): 96-102, 2014], as a result of collaborative research by our company and National Defense Medical College.
August 6, 2014: Research of ‘‘Therapeutic efficacy of subcutaneous administration with hydrogen-included transfusion on the progression of feline chronic kidney disease’’ employing the nondestructive hydrogen adding method will be presented at the 7th Congress of Japanese Association of Veterinary Nephrology and Urology held on August 24, 2014, as a result of collaborative research by our company and Sakata Medical and Nursing Care Animal Clinic Co., Ltd.
July 3, 2014: A document titled ‘‘Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study’’ employing the nondestructive hydrogen adding method is disclosed in the journal of International Immunopharmacology, as a result of collaborative research by our company and Haradoi Hospital.
→ Link: http://www.sciencedirect.com/science/article/pii/S1567576914002124
July 3, 2014: A document titled ‘‘Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes’’ is disclosed in the journal of Scientific Reports (Online offshoot magazine of the British scientific journal Nature), as a result of collaborative research by our company and National Center for Child Health and Development.
→ Link: http://www.nature.com/srep/2014/140630/srep05485/pdf/srep05485.pdf
June 21, 2014: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Taiwan (PAT NO: I399338).
April 22, 2014: Research of ‘‘Therapeutic efficacy of infusing 1ppm molecular hydrogen-resolved saline on rheumatoid arthritis ’’ employing the nondestructive hydrogen adding method will be presented at the 58th Annual Assembly and Scientific Meeting of the Japan College of Rheumatology held on April 25, 2014, as a result of collaborative research by our company, Haradoi Hospital and Midorino Clinic.
April 4, 2014: "Hydrogen adding equipment for living organism applicable fluid" was granted a patent in Hong Kong (PAT NO: HK1172006).
March 20, 2014: "Apparatus for supplying high-concentration hydrogen gas for living organism" was granted a patent in Japan (PAT NO: 5502973).
March 11, 2014: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Taiwan (PAT NO: I429583).
February 20, 2014: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Australia (PAT NO: 2011277514).
February 3, 2014: Research of ‘‘Therapeutic intervention with molecular hydrogen for bronchopulmonary dysplasia (BPD) in neonates’’ employing the super-saturated hydrogen generating apparatus was presented at the 4th Symposium of Medical Molecular Hydrogen held on February 1 and 2, 2014, as a result of collaborative research by our company and Nagoya University of Graduate School of Medicine.
February 3, 2014: Research of ‘‘Anti-inflammatory effects of water containing a high concentration (5-7 ppm) of molecular hydrogen on rheumatoid arthritis (RA)’’ employing the super-saturated hydrogen generating apparatus and nondestructive hydrogen adding method was presented at the 4th Symposium of Medical Molecular Hydrogen held on February 1 and 2, 2014, as a result of collaborative research by our company and Haradoi Hospital.
February 3, 2014: Research of ‘‘Hydrogen-rich preservation solutions improve cell viability of osteochondral tissues after cold preservation’’ employing the nondestructive hydrogen adding method was presented at the 4th Symposium of Medical Molecular Hydrogen held on February 1 and 2, 2014, as a result of collaborative research by our company and Kitasato University Graduate School of Medical Science.
February 3, 2014: Research of ‘‘Combination treatment with H2 water and H2 gas for hepatocellular carcinoma in a mouse model of non-alcoholic steatohepatitis’’ employing the super-saturated hydrogen generating apparatus was presented at the 4th Symposium of Medical Molecular Hydrogen held on February 1 and 2, 2014, as a result of collaborative research by our company and Chubu University.
February 3, 2014: Research of ‘‘Effects of hydrogen-rich water on palatal wound healing in rats’’ employing the super-saturated hydrogen generating apparatus was presented by The University of Tokushima Graduate School, at the 4th Symposium of Medical Molecular Hydrogen held on February 1 and 2, 2014.
January 30, 2014: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Hong Kong (PAT NO: HK1173427).
January 30, 2014: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Taiwan (PAT NO: HK1172602).
January 20, 2014: Research of ‘‘Subcutaneous administration with hydrogen-included transfusion suppresses the progression of feline chronic kidney disease (CKD)’’ employing the non-destructive hydrogen adding method will be presented at the 4^th Symposium of Medical Molecular Hydrogen held on February 1 and 2, 2014, as a result of collaborative research by our company and Sakata Medical and Nursing Care Animal Clinic Co., Ltd.
January 15, 2014: "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE SAME" was granted a patent in Singapore (PAT NO: 174176).
November 7, 2013: Research of ‘‘Efficacy of molecular hydrogen- included preservation water on ischemia-reperfusion injury in small intestine transplantation of swine’’ employing the non-destructive hydrogen adding method will be presented at the 40^th Congress of Japan Society for Organ Preservation and Medical Biology held on November 9 and 10, 2013, as a result of collaborative research by our company and National Center for Child Health and Development.
November 5, 2013: "Instrument for nondestructively producing high-concentration hydrogen solution" was granted a patent in US (PAT NO: 8574503B2).
November 5, 2013: Research of ‘‘Effects of intravenous administration of hydrogen-included saline on oxidative stress in thoroughbred horses following very intense exercise’’ employing the non-destructive hydrogen adding method will be presented at the 26 ^th Annual Meeting of Japanese Society of Equine Science held on December 2 and 3, 2013, as a result of collaborative research by our company, Yamazaki Horse Clinic, Miho Training Center in Japan Racing Association, Ecomo International Co., Ltd., and Yamanashi University.
Ocotober 30, 2013: "Hydrogen adding equipment for living organism applicable fluid" was granted a patent in China (PAT NO: ZL201180007759.7).
October 24, 2013: "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE SAME" was granted a patent in Indonesia (PAT NO: ID P 000 034818).
September 24, 2013: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Korea (PAT NO: 10-1313358).
August 14, 2013: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in China (PAT NO: ZL20118001790.8).
July 29, 2013: "Instrument for nondestructively producing high-concentration hydrogen solution" was granted a patent in Korea (PAT NO: 10-1292859).
July 8, 2013: A document titled ‘‘Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity’’ employing the nondestructive hydrogen adding method is disclosed in the journal of Medical Gas Research, as a result of collaborative research by our company and Fukushima Medical University.
→ Link: http://www.medicalgasresearch.com/content/pdf/2045-9912-3-14.pdf
July 8, 2013: A document titled ‘‘Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies’’ employing the nondestructive hydrogen adding method is disclosed in the journal of Medical Gas Research, as a result of collaborative research by our company and National Defense Medical College.
→ Link: http://www.medicalgasresearch.com/content/pdf/2045-9912-3-13.pdf
June 21, 2013: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in China (PAT NO: I399338).
June 21, 2013: "Instrument for nondestructively producing high-concentration hydrogen solution" was granted a patent in China (PAT NO: I399344).
June 11, 2013: "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE SAME" was granted a patent in US (PAT NO: 8460861).
March 22, 2013: "Apparatus for supplying high-concentration hydrogen gas for living organism" was granted a patent in Japan (PAT NO: 5228142).
March 21, 2013: "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE SAME" was granted a patent in Taiwan (PAT NO: 5091364).
March 21, 2013: Research of ‘Effects of hydrogen-included water on ischemia-reperfusion injury in small intestine’ employing the super-saturated hydrogen generating apparatus and nondestructive hydrogen adding method was presented at the 25th Japanese Society for Small Bowel Transplantation held on March 16, 2013.
March 21, 2013: A document titled ‘Pilot study of H(2) therapy in Parkinson's disease: A randomized double-blind placebo-controlled trial’ employing the super-saturated hydrogen generating apparatus was disclosed in the journal of Movement Disorders.
March 15, 2013: "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE SAME" was granted a patent in Hong Kong (PAT NO: HK1151455).
March 8, 2013: A document titled ‘The final results of controversy in hydrogen water. A real water and an imitation water obtained from experiment by magazine’ employing the super-saturated hydrogen generating apparatus was disclosed in the weekly magazine of Shukan Bunshun published on February 28, and it was demonstrated that concentration of molecular hydrogen using the apparatus is 5.0 ppm and is 5 to 50 times higher than those of other commercially available hydrogen waters.
February 27, 2013: A document titled ‘A novel method of preserving cardiac grafts using a hydrogen-rich water bath’employing the nondestructive hydrogen adding method is disclosed in The Journal of Heart and Lung Transplantation.
February 27, 2013: Research of ‘Effects of hydrogen-saturated water on monocrotaline-induced pulmonary hypertension in a rat model’ using the electrolytic cell and an electrolytic water generating apparatus was presented at the 3th Symposium of Medical Molecular Hydrogen held on February 9, 2013.
February 27, 2013: Research of ‘Administration of hydrogen water delays the disease onset of amyotrophic lateral sclerosis in a mouse model’ using the electrolytic cell and an electrolytic water generating apparatus was presented at the 3th Symposium of Medical Molecular Hydrogen held on February 9, 2013.
February 27, 2013: Research of ‘Examination of hydrogen concentrations in expiratory gas when ingested with hydrogen water and non-digestible saccharides’ using the electrolytic cell and an electrolytic water generating apparatus was presented at the 3th Symposium of Medical Molecular Hydrogen held on February 10, 2013.
January 31, 2013: "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Korea (PAT NO: 10-1230792).
January 31, 2013: "Hydrogen adding equipment for living organism applicable fluid" was granted a patent in Korea (PAT NO: 10-1230783).
January 23, 2013: Research of ‘Pharmacokinetic analyses by measurement of tissue concentrations in rats treated with molecular hydrogen in various administration routes ’ using the super-saturated hydrogen generating apparatus and biological hydrogen gas supplying apparatus will be presented at the 3th Symposium of Medical Molecular Hydrogen held on February 10, 2013.
January 23, 2013: Research of ‘Randomized and double blind controlled trial with hydrogen water for Parkinson’s patients’ using the electrolytic cell and an electrolytic water generating apparatus will be presented at the 3th Symposium of Medical Molecular Hydrogen held on February 10, 2013.
December 2, 2012: Research of 'Effect of foot bath treatment with hydrogen rich water on legs lesion and ulcer in refractory arteriosclerosis obliterans' using the nondestructive hydrogen adding method will be presented at the 87th Scientific Meeting of the Fukushima Renal Failure Association.
November 16, 2012: Research of 'Development of organ preservation solution by nondestructive hydrogen adding treatment in small bowel transplantation' using the nondestructive hydrogen adding method and super-saturated hydrogen generating apparatus will be presented at the 39th Japan Society for Organ Preservation and Medical Biology.
November 10, 2012: "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE SAME" was granted a patent in Russia (PAT NO: 2465910).
October 20, 2012: The website has been revised. A ‘What is molecular hydrogen?’ page has been newly added.
October 12, 2012: Research of ‘Randomized and double blind controlled trial with hydrogen water for Parkinson’s patients’ using electrolytic cell and an electrolytic water generating apparatus will be presented at the 6^th Annual Meeting of the Movement Disorder Society of Japan.
October 5, 2012: "Apparatus for supplying high-concentration hydrogen gas for living organism" was granted a patent in Japan (PAT NO: 5100911).
October 02, 2012: A document titled “Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study” employing the super-saturated hydrogen generating apparatus is disclosed in Medical Gas Research.
September 22, 2012: Research of ‘Clinical trial of dialysis water contained with molecular hydrogen’ using the nondestructive hydrogen adding method will be presented at the 18^th Annual Meeting of the Japanese Society for Peritoneal Dialysis.
September 21, 2012: "Apparatus for supplying hydrogen gas for living organism" was granted a patent in Japan (PAT NO: 5091364).
August 31, 2012: ‘Research on measurement of hydrogen concentration for each internal organ through oral ingestion of hydrogen-rich water’ employing the super-saturated hydrogen generating apparatus will be presented at the 59^th Convention of the Japanese Society for Food Science and Technology.