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Archive
- April 13, 2022
-
A paper titled "
Molecular Hydrogen as a Medical Gas for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Potential Efficacy Based on a Literature Review"
was published online in the Frontiers in Neurology (Swiss international medical journal of neurology) as a collaborative research between our company and Professor Emeritus Yoshiyasu Takefuji of Keio University.
- February 15, 2022
-
MiZ Company Limited has joined the Shonan Health Innovation Park (Shonan iPark) as a member from February 15, 2022.
Shonan iPark HP: https://www.shonan-health-innovation-park.com/
- October 13, 2021
- The results of joint research with the Department of Otorhinolaryngology and Head and Neck Surgery, Ehime University School of Medicine, were presented at the 31st Annual Meeting of the Japanese Society for Otolaryngology and Academic Lectures (Tokyo).
Title: Hydrogen therapy for sudden hearing loss
Results: In a double-blind study, the cure rate of sudden hearing loss with high severity was improved from 20% (placebo) to 60% by inhalation of hydrogen gas. The results of this study have been applied for a patent.
- October 12, 2021
- “COMPOSITION FOR IMPROVING SYMPTOM OF SPINE/SPINAL CORD INJURY” was allowded a patent in Japan （Application No. 2019-108027）.
- October 5, 2021
- “MOLECULAR HYDROGEN-CONTAINING COMPOSITION FOR PREVENTION AND/OR IMPROVEMENT OF INFLAMMATORY BOWEL DISEASE” was allowded a patent in Japan （Application No. 2020-019226）.
- September 30, 2021
- A press release was sent out across the U.S. introducing an academic paper by MiZ Corporation (Jump to the press release).
Title : MiZ Company Limited Publishes Review Article on Discovery of Diatomic Molecule That Overcomes Diseases Caused by Chronic Inflammation, Incurable by Modern Medicine.
- August 16, 2021
- A review titled " Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression " (Int J Mol Sci, 2021, 22, 8724) by MiZ Company Limited, University of California and Keio University is disclosed in International Journal of Molecular Science (international scientific online journal based in Switzerland).
- July, 14, 2021
- “RADIATION DAMAGE PROTECTIVE AGENT” was granted a patent in JP (PAT No. 6923164).
- July 6, 2021
- A review titled "Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases" (Int J Mol Sci, 2021, 22, 7211) by MiZ Company Limited, University of California and Keio University is disclosed in International Journal of Molecular Science (international scientific online journal based in Switzerland). Additionally, we did a press release on this paper.
- June 15, 2021
- "METHOD FOR TREATING SCHIZOPHRENIA" was granted a patent in USA （Pat. No. 11,033,574）.
- June 6, 2021
- “Composition for treatment or prevention of age-related macular degeneration comprising molecular hydrogen” was allowded a patent in USA （Application No. 16/428324）.
- May 27, 2021
- "Composition for improving renal function in kidney diseases containing molecular hydrogen." was granted a patent in Japan （Pat. No. 6890353）.
- April 28, 2021
- A review titled " Molecular hydrogen as a potential clinically applicable radioprotective agent " by MiZ
Company Limited, Keio University and University of California is disclosed in International Journal of
Molecular Science (international scientific online journal based in Switzerland). Int J Mol Sci,
2021, 22,
4566
- April 28, 2021
- An original document titled "Protective effects of hydrogen gas inhalation on radiation-induced bone marrow
damage in cancer patients: a retrospective observational study" is disclosed in the Medical Gas Research
(international medical gas journal based in Netherlands), as a result of collaborative research with our
company, National Institute for Child Health and Development, Osaka University, Kansai Medical Hospital, and
Keio University. Med Gas Res, 2021; 11(3): 104-109
- April 15, 2021
- “Composition for the treatment of schizophrenia” was allowded a patent in USA （Pat Application No.
16/521192）.
- March 5, 2021
- A review titled " Potential therapeutic applications of hydrogen in chronic inflammatory diseases: possible
inhibiting role on mitochondrial stress " by MiZ Company Limited, Keio University and University of California
is disclosed in International Journal of Molecular Science (international scientific online journal based in
Switzerland). Int. J. Mol. Sci., 2021, 22,
2549
- February 24, 2021
- A document titled " Hydrogen gas therapy attenuate inflammatory pathway signaling in septic mice" is
disclosed in the Journal of Surgical Research (international medical research), as a result of collaborative
research with our company and Osaka University.
- December, 16 ,2020
- A review titled "Hydrogen Is Promising for Medical Applications" by MiZ Company Limited and Keio University
is disclosed in Clean Technologies (international scientific online journal based in Switzerland). Clean Technol. 2020, 2(4), 529-541
- November, 27 ,2020
- “Composition containing hydrogen for suppressing or alleviating cancer pain” was granted a patent in JP (PAT
NO: JP6800492).
- November, 13 ,2020
- “Hydrogen gas inhaler” was allowed a design registration in Japan (Design Application No. 2020-004474).
- November, 5, 2020
- “Composition containing hydrogen for suppressing or alleviating cancer pain” was allowed a patent in Japan
(PAT Application No. 2018-124626).
- October, 20 ,2020
- “Composition containing gaseous hydrogen for suppressing or preventing cancer metastasis” was granted a
patent in JP (PAT NO: JP6781485).
- October, 20, 2020
- A joint research with Osaka University Hospital (Department of Traumatology and Acute Critical Medicine)
"COMPOSITION FOR PREVENTING OR INHIBITING BACTERIAL TRANSLOCATION " overcame the decision of refusal in a
trial against the decision of refusal and received a patent (Japanese Patent Application No. 2017-242471).
- October, 1, 2020
- A proposal titled “Proposal of Next-Generation Medical Care "Mega-hydrogen Therapy"” by MiZ Company Limited
and Keio University is disclosed in the journal of Medical Gas Research (international scientific online
journal based in Netherlands).
- September, 29, 2020
- The patent application titled "Composition containing gaseous hydrogen for suppressing or preventing cancer
metastasis" overcame the decision of refusal in a trial against the decision of refusal and received a patent
(Japanese Patent Application No. 2019-056298).
- June, 30, 2020
- “AGENT FOR INHIBITING DETERIORATION OF RECOGNITION FUNCTION, COMPRISING HYDROGEN GAS” was allowed a patent
in Japan (PAT Application No. 2019-102366).
- July, 20, 2020
- A document titled “Protective effects of
a hydrogen-rich preservation solution in a canine lung transplantation model” is disclosed in The Annals
of Thoracic Surgery (international scientific journal in the thoracic surgery), as a result of collaborative
research with our company and Kyoto university. This paper demonstrated that hydrogen-rich preservation
solution attenuated ischemia-reperfusion injury in a canine lung transplantation model.
- July, 7, 2020
- “Hydrogen-containing composition for improving depression” was allowed a patent in Japan (PAT Application
No. 2018-164456).
- June, 30, 2020
- “Hydrogen-containing composition (composition used to improve PTSD)” was allowed a patent in Japan (PAT
Application No. 2019-102366).
- April, 15, 2020
- “Hydrogen gas generator” was granted a patent in JP (PAT NO: GB2544147).
- March, 19, 2020
- "Producing method for living organism-applicable hydrogen-contained fluid and producing apparatus" was
granted a patent in Thailand (PAT NO:72857).
- March 18, 2020
- A proposal titled “A philosophical molecule, hydrogen may
overcome senescence and intractable diseases” by MiZ Company Limited and Keio University is disclosed in
the journal of Medical Gas Research (international scientific online journal based in Netherlands).
- February, 28, 2020
- “Hydrogen gas supply apparatus for living organism” was granted a patent in JP (PAT NO: 6667873).
- February 17, 2020
- A document titled "Hydrogen gas attenuates hypoxic-ischemic
brain injury via regulation of the MAPK/HO-1/PGC-α pathway in neonatal rats" is disclosed in the journal
of Oxidative Medicine and Cellular Longevity (international scientific online journal for oxidative medicine),
as a result of collaborative research with our company, National Research Institute for Child Health and
Development, and Central South University in China. In this document, we have reported the effectiveness of
hydrogen gas on hypoxic-ischemic brain injury in neonatal rats and its mechanisms.
- January, 15, 2020
- “Hydrogen Gas Generator” was allowed a patent in Great Britain (PAT Application No. 1613734.1).
- December 13, 2019
- A joint research with Nagoya University Hospital (Department of Thoracic Surgery) "Composition for
suppressing or ameliorating obstructive airway disease" was granted a patent in JP (PAT NO. 6628449).
- December 10, 2019
- A document titled “Protective effects
of a hydrogen-rich solution during cold ischemia in rat lung transplantation” is disclosed in The
Journal of Thoracic and Cardiovascular Surgery (an official journal of The American Association for Thoracic
Surgery). This paper demonstrated that hydrogen-rich water protected the ischemia-reperfusion injury in lung
transplantation.
- November 19, 2019
- "Producing method for living organism-applicable hydrogen-contained fluid and producing apparatus" was
allowed a patent in Thailand (PAT Application No. 1101001990).
- November 12, 2019
- A joint research with Nagoya University Hospital (Department of Thoracic Surgery) "Composition for
suppressing or ameliorating obstructive airway disease" was allowed a patent in JP (PAT Application
JP2018-1452542).
- November 1, 2019
- “Apparatus and method for producing hydrogen-containing liquid” was granted a patent in JP (PAT NO:
6607647).
- October 18, 2019
- A joint research with Osaka University (Department of Traumatology and Acute Critical Medicine) "A
composition for preventing or improving an abnormal bacterial species composition in the intestinal flora."
was granted a patent in JP (PAT No. 6601851).
- September 24, 2019
- A document titled "Preventing explosions
of hydrogen gas inhalers" is disclosed in the journal of Medical Gas Research (international scientific
online journal based in Netherlands), as a result of collaborative research with our company and Keio
University. In this document, we have reported the safe of hydrogen gas inhaler.
- September 19, 2019
- A document titled "Hydrogen water
alleviates obliterative airway disease in mice" is disclosed in General Thoracic and Cardiovascular
Surgery (international scientific journal in the thoracic and cardiovascular surgery). This paper demonstrated
that hydrogen water alleviated the obliterative airway disease in mice.
- September 5, 2019
- A joint research with Osaka University (Department of Traumatology and Acute Critical Medicine) "A
composition for preventing or improving an abnormal bacterial species composition in the intestinal flora."
was allowed a patent in JP (PAT Application JP2017-242401).
- August 31, 2019
- In the 9th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Nishitetsu Grand
Hotel on August 31, 2019, as a result of collaboration study between MiZ Co., Ltd. and Kyoto University
(Department of surgery, Division of Hepato-Biliary-Pancreatic surgery and transplantation), a research report
was presented using MiZ’s super-saturated hydrogen water, titled “Novel Application of Molecular Hydrogen in
Organ Preservation & Transplantation: Biphasic Combination of Hydrogen Flush After Cold Storage (HyFACS)
Hydrogen Inhalation After Reperfusion (HyIAR)”.
- July, 5, 2019
- A document titled “Hydrogen inhalation protects hypoxic-ischemia
brain damage by attenuating inflammation and apoptosis in neonatal rats” is disclosed in Experimental
Biology and Medicine. This paper demonstrated that hydrogen gas inhalation protects hypoxic-ischemic brain
damage in neonatal rats.
- May, 22, 2019
- “METHOD AND DEVICE FOR PRODUCING HYDROGEN-CONTAINING BIOLOGICAL APPLICATION SOLUTION” was granted a patent
in EU (PAT No: EP2985028)
- April, 23, 2019
- MiZ Co., Ltd. has been registered as "Kanagawa SDGs Partner" (registration certificate).
The registration certificate was awarded by the Governor of Yuji Kuroiwa at the registration certificate award
ceremony at the Kanagawa Prefectural Government Office.
- April, 6, 2019
- As a result of collaboration study between MiZ Co., Ltd. and Kyoto University Hospital, Department of
Respiratory surgery, “Hydrogen-rich preservation
solution attenuates lung ischemia-reperfusion injury after prolonged cold ischemia in a canine left lung
transplant model” was presented at the International Society of Heart and Lung Transplantation (ISHLT)
held in Orlando, USA.
- March, 26, 2019
- “SELECTED HYDROGEN ADDING EQUIPMENT FOR LIVING ORGANISM APPLICABLE FLUID” was granted a patent in US (PAT
NO: 10,238,232)
- March, 21, 2019
- As a result of collaboration study between MiZ Co., Ltd. and National Defense Medical College, a research
report was presented using MiZ’s non-destructive hydrogen adding apparatus, titled ”Randomized controlled
trial of the efficacy of hydrogen instillation and intravesical magnesium administration for patients with
severe subarachnoid hemorrhage”, in the Meeting of 35 th Meeting of the SPASM symposium held at PACIFICO
YOKOHAMA on March, 21, 2019.
https://www.micenavi.jp/stroke2019/search/detail_session/id:40
- March, 8, 2019
- “METHOD FOR SUPRESSION OF OR PROTECTION FROM ISCHEMIA/REPERFUSION INJURY OF ORGANS FOR TRANSPLANTATION” was
granted a patent in India (PAT NO: 6489535)
- February, 19, 2019
- A document titled “Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver
transplantation” is disclosed in BMC Gastroenterogy .
This research report was presented using MiZ’s Non-destructive hydrogen adding apparatus.
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-019-0939-7
- December 18, 2018
- “METHOD AND DEVICE FOR PRODUCING HYDROGEN CONTAINING FULUID” was granted a patent in India (PAT NO:304570)
- December 18, 2018
- “SELECTIVE HYDROGEN ADDING EQUIPMENT FOR LIVING ORGANISM APPLICABLE FULUID” was granted a patent in USA (PAT
NO:US2015374166(B))
- November 5, 2018
- A document titled “Hydrogen Flush After Cold Storage (HyFACS), as a new end-ischemia ex vivo treatment for
liver grafts against ischemia/reperfusion injury " is disclosed in the journal of Liver Transplantation (an
international journal published by AASLD, American Association for the Study of Liver Diseases), as results of
collaborative research with our company and Kyoto University.
https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/lt.25326
This paper demonstrated that perfusion of hydrogen-containing solution after cold storage for liver grafts
protects against ischemia/reperfusion injury by ameliorating oxidative damages.
- October 8, 2018
- A proposal titled “Radical curatives will play a key role in the universal health care” by MiZ Company
Limited and Keio University was published on the web page of Science, an academic journal with international
authority.
http://science.sciencemag.org/content/361/6404/eaat9644/tab-e-letters
In this article, we demonstrated that for the global health management efforts, we should aim for fundamental
therapy rather than developing individual therapeutic agents.
- October 8, 2018
- A proposal titled “Who will be suffering from losing the Alzheimer’s gamble” by MiZ Company Limited and Keio
University was published on the web page of Science, an academic journal with international authority.
http://science.sciencemag.org/content/361/6405/838/tab-e-letters
In this article, we demonstrated that in order to solve the stagnant Alzheimer's disease study, we should try
safe therapeutic development early.
- September 26, 2018
- A document titled “Molecular hydrogen protects against
ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression" is
disclosed in the journal of Scientific Reports (online offshoot magazine of the British scientific journal
Nature), as results of collaborative research with our company, National Research Institute for Child Health
and Development, Osaka University, and Toyama University. In this document, we have reported that the
super-saturated hydrogen water (7 ppm) markedly protected the ischemia-reperfusion injury using
transplantation model of a mouse fatty liver.
- August 27, 2018
- In the 8th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Bell Classic
Tokyo on August 23 and 24, 2018, as a result of collaboration study between MiZ Co., Ltd. and National Defense
Medical College, a research report was presented using MiZ’s hydrogen gas inhaler, titled “Application of
molecular hydrogen to blast-induced traumatic brain injury”. In addition, the result of this research was
reported as the scientific journal (https://www.ncbi.nlm.nih.gov/pubmed/30053086)
- August 27, 2018
- In the 8th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Bell Classic
Tokyo on August 23 and 24, 2018, as a result of collaboration study between MiZ Co., Ltd. and Osaka
University, a research report was presented using MiZ’s super-saturated hydrogen water, titled “Hydrogen-rich
saline regulates intestinal barrier dysfunction, dysbiosis, and bacterial translocation in a murine model of
sepsis”. In addition, the result of this research was reported as the scientific journal (https://www.ncbi.nlm.nih.gov/pubmed/29293174)
- August 27, 2018
- In the 8th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Bell Classic
Tokyo on August 23 and 24, 2018, as a result of collaboration study between MiZ Co., Ltd. and Nagoya
University, a research report was presented using MiZ’s super-saturated hydrogen water, titled “Molecular
hydrogen induces mitochondrial unfolded response (mtUPR)”.
- July 11, 2018
- "Method of obtaining hydrogen concentration in hydrogen-containing liquid and generator for
hydrogen-containing liquid " was granted a patent in Taiwan (PAT No: I629480).
- July 5, 2018
- "APPARATUS AND METHOD FOR PRODUCING HYDROGEN-CONTAINING LIQUID" was granted a patent in India (PAT
No:298525).
- June 7, 2018
- "APPARATUS, METHOD and KIT FOR PRODUCING HYDROGEN-CONTAINING LIQUID" was granted a patent in Korea (PAT No:
JP10-186348(B)).
- June 6, 2018
- "APPARATUS AND METHOD FOR PRODUCING HYDROGEN-CONTAINING LIQUID" was granted a patent in Japan (PAT No:
JP6340033(B)).
- April 16, 2018
- In the 38th Annual Meeting of International Society for Heart and Lung Transplantation held at
Nice in France on April 11 to 14, 2018, as a result of collaboration study between MiZ Co., Ltd. and Kyoto
University, a research report was presented, using MiZ's super-saturated hydrogen water, titled “Protective effect of hydrogen-rich preservation solution
during cold ischemia in rat lung transplantation”.
- March 26, 2018
- A research study by our Company on problems about explosive hydrogen concentration of hydrogen gas inhaler
was disclosed in the Direct Marketing News, a newspaper of direct marketing, published on March 22, 2018.
- February 19, 2018
- “High-Concentration Hydrogen Gas Supply Device for Living Bodies” was granted a patent in Hong Kong (PAT No:
HK1204346).
- February 15, 2018
- A document titled “Hydrogen-rich saline regulates
intestinal barrier dysfunction, dysbiosis and bacterial translocation in a murine model of sepsis" is
disclosed in the journal of Shock (international scientific journal in the area of emergency medicine), as
results of our company and Osaka University Graduate of Medicine. In this document, we have reported that the
super-saturated hydrogen water (7 ppm) markedly improved survival rate in a murine model of sepsis, via the
regulation of intestinal barrier dysfunction, dysbiosis and bacterial translocation.
- December 15, 2017
- A research study by our Company on problems about hydrogen supplement was disclosed in the Direct Marketing
News, a newspaper of direct marketing, published on December 14, 2017.
- November 9, 2017
- “Method and device for producing a hydrogen containing fluid applicable to a living organism” was granted a
patent in China (PAT No: ZL201580000856. 1).
- November 6, 2017
- “Selective hydrogen adding equipment for living organism applicable fluid” was granted a patent in Indonesia
(PAT No: P000044303).
- November 2, 2017
- In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden
Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd., Clinic C4,
National Institute for Child Health and Development and Osaka University Graduate School of Medicine,
Shin-ichi HIRANO, Managing Director of MiZ Co. Ltd., presented a research report using hydrogen gas inhalers
titled “Hyperbaric hydrogen gas inhalation attenuates bone
marrow damage in cancer patients induced by radiotherapy”.
- November 2, 2017
- In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden
Palace on October 29 and 30, 2017, Ryosuke KUROKAWA, General Manager of Research and Development of MiZ Co.,
Ltd., presented a study titled “Explosive concentration of
hydrogen gas and safety of hydrogen gas inhaler”.
- November 2, 2017
- In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden
Palace on October 29 and 30, 2017, Tomoki SEO, Director of MiZ Co., Ltd., presented a study titled “Analysis result of hydrogen supplement sold at a market”.
- November 2, 2017
- In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden
Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and Juntendo
University, a research report was presented using MiZ’s super-saturated hydrogen water, titled “A randomized
double-blind, placebo-controlled multi-center trial of molecular hydrogen water for Parkinson’s disease”.
- November 2, 2017
- In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden
Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and Chubu
University, a research report was presented, using MiZ’s super-saturated hydrogen water, titled “Molecular
hydrogen alters gene expression via epigenetic mechanism and activates mitochondrial unfolded protein response
for the protection against stress-induced damage”.
- November 2, 2017
- In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden
Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and Juntendo
University, a research report was presented, using MiZ’s super-saturated hydrogen water, titled “Hydrogen-rich
pure water prevents cigarette smoked-induced pulmonary emphysema in SMP30 knockout mice”.
- November 2, 2017
- In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden
Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and Kyoto
University, a research report was presented, using MiZ’s non-destructive adding apparatus, titled “Protective
effect of hydrogen-rich solution during lung cold preservation in rats”.
- November 2, 2017
- In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden
Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and Kyoto
University, a research report was presented, using MiZ’s, non-destructive adding apparatus, titled “Hydrogen
perfusion after cold storage; A new, simple, and non-invasive graft conditioning for ameliorating hepatic
ischemia/reperfusion injury”.
- November 2, 2017
- In the 7th Meeting of the Japanese Biomedical Association of Molecular Hydrogen held at Hotel Nagoya Garden
Palace on October 29 and 30, 2017, as a result of collaboration study between MiZ Co., Ltd. and National
Defense Medical College, a research report was presented, using MiZ ‘s non-destructive hydrogen adding
apparatus, titled “Combination therapy of intravenous hydrogen saturated solution and intracisternal magnesium
sulfate infusion to rat subarachnoid hemorrhage model”.
- August 24, 2017
- An interview document titled as “Agency sales of hydrogen gas inhaler sales business is in good demand” from
Shin-ichi Hirano, Managing Director, Research and Development of MiZ Company Limited was disclosed in the
Nippon Distribution Industry Newspaper published on August 24, 2017.
- August 23, 2017
- “Method of adding hydrogen to a fluid that is applicable to living organism” was granted a patent in Europe
(PAT No: 3026025).
- August 3, 2017
- An interview document titled as “Future prospect in hydrogen gas area” from Shin-ichi Hirano, Managing
Director, Research and Development of MiZ Company Limited was disclosed in the Direct Marketing News, a
specialty paper of direct marketing in Japan, published on August 8, 2017.
- August 1, 2017
- “Apparatus for supplying high-concentration hydrogen gas for living organism” was granted a patent in USA
(PAT No: 9717877).
- Jury 21, 2017
- “Apparatus for generating hydrogen gas” was granted a patent in Taiwan (PAT No: I592518).
- July 7, 2017
- “Method for producing hydrogen water” (PAT No: 6169762) , “Nasal cannula” (PAT No: 6169771) , and “Method
for producing hydrogen-containing liquid” (PAT No: 6170605) were granted patents in Japan.
- June 5, 2017
- We renewed our home page on "Applied Technologies" in association with our
development of high-concentration hydrogen water generator directly connected with tap water pipes.
- May 26, 2017
- “Method of obtaining hydrogen concentration in hydrogen-containing liquid and generator for
hydrogen-containing liquid” was granted a patent in Japan (PAT NO: 6148759).
- May 4, 2017
- An article on Media Workshop presented by Molecular Hydrogen Clinical Engineering Association (Incorporated
Corporation) appeared on “News on Sales” (industry newspaper for visiting sales) in its May 4, 2017
publication.
- April 18, 2017
- Shin-ichi Hirano, Managing Director, Research and Development of MiZ Company Limited, made a presentation
titled as “Current situation and future prospect on medical research on molecular hydrogen” at the Media
Workshop presented by Molecular Hydrogen Clinical Engineering Association (Incorporated Corporation) held at
Tokyo Station Conference on April 13, 2017.
- December 27, 2016
- On December 15, 2016, National Life Center (Independent Administrative Agency) opened the product test
result titled as “Hydrogen water for drinking or hydrogen water produced in bottles or by inhalers has no
official definition etc. and there are different hydrogen concentration on these products.”
- December 15, 2016
- We will have an exhibition in The 50th Annual Meeting of the Japanese Society for Clinical Renal
Transplantation on February 15 to 17, 2017 at Kobe Convention Center, in order to introduce the representative
technologies of our company.
- November 23, 2016
- "Producing method for living organism-applicable hydrogen-contained fluid and producing apparatus for the
same" was granted a patent in Europe (PAT NO: 2 407 141).
- November 11, 2016
- We will have an exhibition in the Direct Marketing Fair 2016 held at Tokyo Big Sight on December 6 and 7,
2016, in order to introduce the representative technologies of our company, such as non-destructive hydrogen
adding devices, super-saturated hydrogen water, hydrogen gas inhaler, and dissolved hydrogen concentration
measuring reagent.
- November 11, 2016
- Research of "Perfusion of hydrogen-containing solution via portal vein after preservation of transplanted
liver alleviates the ischemia and reperfusion injury" employing the non-destructive hydrogen adding devices
will be presented at The 43th Annual Meeting of Japan Society for Organ Preservation and Biology 2016 held on
November 26 and 27, 2016, as a result of collaborative research by our company and Kyoto University.
- September 13, 2016
- We will have an exhibition in The 22nd Annual Meeting of the Japanese Society for Peritoneal Dialysis held
at International Conventioncenter PAMIR of Sapporo Prince Hotel on September 24 to 25, 2016, in order to
introduce the representative technologies of our company.
- September 7, 2016
- "Apparatus for supplying high-concentration hydrogen gas for living organism" was granted a patent in Europe
(PAT NO: 2 857 555).
- August 29, 2016
- "Method and device for producing a hydrogen containing fluid applicable to a living organism" was granted a
patent in Korea (PAT NO: 10-165393).
- June 3, 2016
- Research of ‘‘Proposal of a new therapeutic strategy intravenous infusion of hydrogen-rich fluid combined
with intra-cisternal infusion of magnesium sulfate” using the nondestructive hydrogen adding apparatus was
presented in The 6th Annual Meeting of Japan Molecular Hydrogen Biomedical Society at The Wakupia Yokohama on
May 29 2016, as a result of collaborative research by our company and National Defense Medical College.
- June 3, 2016
- Research of ‘‘Molecular hydrogen; a potential relaxing factor of peripheral blood vessels” using the super
saturated hydrogen water and nondestructive hydrogen adding apparatus was presented in The 6th Annual Meeting
of Japan Molecular Hydrogen Biomedical Society at The Wakupia Yokohama on May 28 2016, as a result of
collaborative research by our company and Huis Ten Bosch Satellite H2 Clinic Hakata.
- June 3, 2016
- Research of ‘‘Combination therapy of intravenous hydrogen saturated solution and intra-cisternal magnesium
sulfate infusion to rat subarachnoid hemorrhage model” using the nondestructive hydrogen adding apparatus was
presented in The 6th Annual Meeting of Japan Molecular Hydrogen Biomedical Society at The Wakupia Yokohama on
May 28 2016, as a result of collaborative research by our company and National Defense Medical College.
- June 3, 2016
- Research of ‘‘A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease:
protocol and baseline characteristics” using the super saturated hydrogen water was presented in The 6th
Annual Meeting of Japan Molecular Hydrogen Biomedical Society at The Wakupia Yokohama on May 28 2016, as a
result of collaborative research by our company and Juntendo University.
- May 18, 2016
- We will have an exhibition in The 75th Annual Meeting of the Japanese Cancer Association held at Pacifico
Yokohama on October 6 to 8, 2016, in order to introduce the representative technologies of our company.
- May 18, 2016
- We will have an exhibition in The 38th Congress of Japan Respiratory Therapy Medical Association held at
Nagoya Congress Center on Jury 16 and 17, 2016, in order to introduce the representative technologies of our
company.
- May 18, 2016
- We will have an exhibition in The 21th Congress of Japan Society of Palliative Medicine held at Kyoto
International Conference Center on June 17 and 18, 2016, in order to introduce the representative technologies
of our company.
- May 6, 2016
- Research of ‘‘Effects of hydrogen saline pretreatment on mouse fatty liver ischemia-reperfusion injury
”employing the super saturated hydrogen saline will be presented held in The 6th Annual Meeting of Japan
Molecular Hydrogen Biomedical Society at The Wakupia Yokohama on May 28, 2016, as a result of collaborative
research by our company, National Institute of Child health and Development, and Toyama University.
- May 6, 2016
- Research of ‘‘Inhalation of hydrogen gas reduces anesthesia- and surgery-induced oxidative stress in dogs
and cats” employing the hydrogen gas inhaler will be presented held in The 6th Annual Meeting of Japan
Molecular Hydrogen Biomedical Society at the Wakupia Yokohama on May 28, 2016, as a result of collaborative
research by our company and Animal Wellness Center.
- April 28, 2016
- We will have an exhibition in The 6th Annual Meeting of Japan Molecular Hydrogen Biomedical Society at the
Wakupia Yokohama on May 28, 2016, in order to introduce the representative technologies of our company.
- April 28, 2016
- An interview document from our company’s corporate officer Shin-ichi Hirano was disclosed in the Direct
Marketing News and Data, a specialty paper of direct marketing, published on April 28, 2016.
- March 22, 2016
- We have revised a page of “What is molecular hydrogen?” in our company’s web site, according to the
development of hydrogen medicine.
- March 22, 2016
- We made the joint research agreement using molecular hydrogen with Central South University in China, for
the animal study of hypoxic-ischemic encephalopathy.
- February 2, 2016
- We have established a home page of the hydrogen gas inhaler. Please refer to the web site as follows:
http://www.mhga.jp/product.html
- January 26, 2016
- We respectively made a joint research agreement using molecular hydrogen with Shanghai Jiaotong University,
Soochow University, and with Huazhong University of Science and Technology in China, for the clinical studies
of liver transplantation, post-stroke depression, and kidney transplantation.
- January 7, 2016
- A document titled "Interview about the future prospects of hydrogen water from our company’s corporate
officer Shin-ichi Hirano" was disclosed in the Houhan News, a specialty paper of door-to-door sales industry,
published on January 7, 2016.
- January 7, 2016
- A document titled "MiZ Co., Ltd. has published a paper in the Medical Gas Research, an US scientific
journal" was disclosed in the Houhan News, a specialty paper of door-to-door sales industry, published on
November 26, 2015.
- October 28, 2015
- We will have an exhibition in the Integrated Medicine Exhibition and Conference 2016 held at Tokyo Big Sight
on January 26 and 27, 2016, in order to introduce the representative technologies of our company, such as
nondestructive hydrogen adding apparatus, super-saturated hydrogen water, hydrogen gas inhaler, and dissolved
hydrogen concentration measuring reagent.
- October 28, 2015
- A document titled “Convenient methods for ingestion of molecular hydrogen: drinking, injection, and
inhalation’’ is disclosed in the journal of Medical Gas Research (international scientific online journal
based in United States), as a results of our company’s research and development. In this document, we have
reported the convenient and safe preparatory methods using devices for the ingestion of hydrogen and changes
in the concentration of hydrogen.
→ http://www.medicalgasresearch.com/content/pdf/s13618-015-0034-2.pdf
- October 28, 2015
- It has been introduced in the following document that our company’s research reported in the journal of
Bioscience, Biotechnology, and Biochemistry (English journal published in Japan Society for Bioscience,
Biotechnology, and Agrochemistry) on 2005 was a pioneering work, because we explicitly proved that
hydrogen-rich neutral water reduced oxidative stress in rats.
→ http://www.tandfonline.com/doi/pdf/10.1271/bbb.69.1985
→ http://www.medicalgasresearch.com/content/pdf/s13618-015-0035-1.pdf
- September 3, 2015
- We will have an exhibition in the Direct Marketing Fair 2015 held at Tokyo Big Sight on November 12 and 13,
2015, in order to introduce the representative technologies of our Company, such as nondestructive hydrogen
adding apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and dissolved hydrogen
concentration measuring reagent.
- July 24, 2015
- A document titled "Is the development of hydrogen for drug accelerated, since research of hydrogen has
reached stage of clinical trials?" was disclosed in the magazine of Gas Review (No. 820, trade magazine of
industrial gas) published on Jury 15, 2015, and the information of research and development of our company was
introduced into the journal.
- July 24, 2015
- Research of "Preparation of hydrogen-rich atmosphere in on-tip devices for cell culture system" employing
the dissolved hydrogen concentration measuring reagent will be presented at the Symposium of Medical and
Biological Engineering 2015 held on September 25 and 26, 2015, as a result of collaborative research by our
company, Shibaura Institute of Technology, and National Center for Child Health and Development.
- June 19, 2015
- We will have an exhibition in the Bio Japan 2015 held at Pacifico Yokohama on October 14 to 16, 2015, in
order to introduce the representative technologies of our company, such as nondestructive hydrogen adding
apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and dissolved hydrogen concentration
measuring reagent.
- June 19, 2015
- A document titled “Improvement of psoriasis-associated arthritis and skin lesions by treatment with
molecular hydrogen: A report of three cases” is disclosed in the journal of Molecular Medicine Reports (online
scientific journal based in Italy and England), as a result of collaborative research by our company and
Haradoi Hospital.
→ Link: http://www.biomedcentral.com/content/pdf/s12868-015-0165-3.pdf
- June 19, 2015
- Research of ‘‘Efficacy and its mechanism of hydrogen water on non-alcoholic steatohepatitis (NASH) in mice”
employing the super saturated hydrogen water is presented at the 51th Annual Meeting of Japan Society of
Hepatology held on March 21 and 22, 2015, as a result of collaborative research by our company and Toyama
University.
- May 11, 2015
- A document titled “Hydrogen improves neurological function through attenuation of blood-brain barrier
disruption in spontaneously hypertensive stroke-prone rats” is disclosed in the journal of (international
medical journal based in England), as a result of collaborative research by our company and National Defense
Medical College.
→ Link: http://www.biomedcentral.com/content/pdf/s12868-015-0165-3.pdf
- May 11, 2015
- A document titled “Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion
injury in rats” is disclosed in the journal of Transplantation (Transplantation 2015; 99: 500-507,
international journal in transplantation area), as a result of collaborative research by our company and
National Center for Child Health and Development.
- March 26, 2015
- We will have an exhibition in the BIO tech Japan 2015 held at Tokyo Big Sight on May 13 to 15, 2015, in
order to introduce the representative technologies of our company, such as nondestructive hydrogen adding
apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and dissolved hydrogen concentration
measuring reagent.
- March 26, 2015
- Research of ‘‘Molecular hydrogen’s effects on glycometabolism’’ employing the super-saturated hydrogen water
was presented at the 5th Symposium of Medical Molecular Hydrogen held on March 21 and 22, 2015, as a result of
collaborative research by our company and Nagoya University Graduate School of Medicine.
- March 26, 2015
- Research of ‘‘Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses
signaling pathways in rodents ’’ employing the super-saturated hydrogen water was presented at the 5th
Symposium of Medical Molecular Hydrogen held on March 21 and 22, 2015, as a result of collaborative research
by our company and Chubu University.
- March 26, 2015
- Research of ‘‘Hydrogen supplementation of preservation solution improves viability of osteochondral grafts’’
employing the nondestructive hydrogen adding apparatus was presented at the 5th Symposium of Medical Molecular
Hydrogen held on March 21 and 22, 2015, as a result of collaborative research by our company and Kitasato
University Graduate School of Medical Science.
- March 26, 2015
- Research of ‘‘Molecular hydrogen: a potential mediator of endothelial function’’ employing the
super-saturated hydrogen water and nondestructive hydrogen adding apparatus was presented at the 5th Symposium
of Medical Molecular Hydrogen held on March 21 and 22, 2015, as a result of collaborative research by our
company and Haradoi Hospital.
- March 26, 2015
- Research of ‘‘Changes in the hydrogen concentration in the various devices for ingestion of molecular
hydrogen’’ employing the super-saturated hydrogen water, nondestructive hydrogen adding apparatus, hydrogen
gas supply apparatus, and dissolved hydrogen concentration measuring reagent was presented at the 5th
Symposium of Medical Molecular Hydrogen held on March 21 and 22, 2015, as a result of our company.
- March 26, 2015
- Research of ‘‘Molecular hydrogen reduces muscle degeneration in mdx mice’’ employing the super-saturated
hydrogen water was presented at the 5th Symposium of Medical Molecular Hydrogen held on March 21 and 22, 2015,
as a result of collaborative research by our company and Nagoya University Graduate School of Medicine.
- March 26, 2015
- Research of ‘‘Molecular hydrogen-saturated water attenuates and prevents chronic lung disorder in newborn
rats’’ employing the super-saturated hydrogen water was presented at the 5th Symposium of Medical Molecular
Hydrogen held on March 21 and 22, 2015, as a result of collaborative research by our company and Nagoya
University Graduate School of Medicine.
- March 26, 2015
- Research of ‘‘Effect of the small intestine graft storage using hydrogen-containing storage method in small
intestine transplant model of pig’’ employing the super-saturated hydrogen generating apparatus was presented
at the 27th Japanese Society for Small Bowel Transplantation held on March 14, 2015, as a result of
collaborative research by our company and National Center for Child Health and Development.
- March 6, 2015
- We will have an exhibition in the Tokyo Health Industry Show 2015 held at Tokyo Big Sight on March 11 to 13,
2015, in order to introduce the representative technologies of our company, such as nondestructive hydrogen
adding apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and dissolved hydrogen
concentration measuring reagent.
- March 6, 2015
- A document titled “Simultaneous oral and inhalation intake of molecular hydrogen additively suppresses
signaling pathways in rodents’’ is disclosed in the journal of Molecular and Cellular Biochemistry
(international scientific journal based in United States), as a result of collaborative research by our
company and College of Life and Health Science, Chubu University.
→ Link: http://link.springer.com/article/10.1007/s11010-015-2353-y
- February 13, 2015
- We had an exhibition in the Regenerative Medicine Expo and Conference Japan 2015 held at Intex Osaka on
February 4 to 6, 2015, in order to introduce the representative technologies of our company, such as
nondestructive hydrogen adding apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and
dissolved hydrogen concentration measuring reagent.
- February 13, 2015
- We had an exhibition in the Direct Marketing Fair 2014 held at Tokyo Big Sight on October 21 and 22, 2014,
in order to introduce the representative technologies of our company, such as nondestructive hydrogen adding
apparatus, super-saturated hydrogen water, hydrogen gas supply apparatus, and dissolved hydrogen concentration
measuring reagent.
- January 14, 2015
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in China (PAT
NO: ZL 201280035228.3).
- December 3, 2014
- A document titled “Hydrogen supplementation of preservation solution improves viability of osteochondral
grafts’’ employing the nondestructive hydrogen adding apparatus is disclosed in the journal of The Scientific
World Journal (online scientific journal based in Egypt and United States), as a result of collaborative
research by our company and Kitasato University School of Medicine with School of Allied Health Science.
→ Link: http://www.hindawi.com/journals/tswj/2014/109876/abs/
- December 1, 2014
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Israel
(PAT NO: 229683).
- November 18, 2014
- "Hydrogen adding equipment for living organism applicable fluid" was granted a patent in US (PAT NO:
8,887,625 B2).
- November 5, 2014
- A document titled “Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular
endothelial function’’ employing the super saturated hydrogen water is disclosed in the journal of Vascular
Health and Risk Management (British online scientific journal), as a result of collaborative research by our
company and Haradoi Hospital.
→ Link: http://www.dovepress.com/articles.php?article_id=18794
- October 21, 2014
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Singapore
(PAT NO: 186786).
- October 10, 2014
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Russia
(PAT NO: 2530122).
- September 16, 2014
- New office building of our company was completed, and we moved to the following address. Address: 2-19-15
Ofuna Kamakura, Kanagawa 247-0056, Japan
- August 20, 2014
- A document titled ‘‘Physiological effects of combination therapy of intracisternal infusion of magnesium
sulfate solution and intravenous injection of hydrogen-enriched fluid in the rat’’ employing the
nondestructive hydrogen adding method is disclosed in The Journal of National Defense Medical College [39 (2):
96-102, 2014], as a result of collaborative research by our company and National Defense Medical College.
- August 6, 2014
- Research of ‘‘Therapeutic efficacy of subcutaneous administration with hydrogen-included transfusion on the
progression of feline chronic kidney disease’’ employing the nondestructive hydrogen adding method will be
presented at the 7th Congress of Japanese Association of Veterinary Nephrology and Urology held on August 24,
2014, as a result of collaborative research by our company and Sakata Medical and Nursing Care Animal Clinic
Co., Ltd.
- July 3, 2014
- A document titled ‘‘Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A
randomized, double-blind, placebo-controlled pilot study’’ employing the nondestructive hydrogen adding method
is disclosed in the journal of International Immunopharmacology, as a result of collaborative research by our
company and Haradoi Hospital.
→ Link: http://www.sciencedirect.com/science/article/pii/S1567576914002124
- July 3, 2014
- A document titled ‘‘Estimation of the hydrogen concentration in rat tissue using an airtight tube following
the administration of hydrogen via various routes’’ is disclosed in the journal of Scientific Reports (Online
offshoot magazine of the British scientific journal Nature), as a result of collaborative research by our
company and National Center for Child Health and Development.
→ Link: http://www.nature.com/srep/2014/140630/srep05485/pdf/srep05485.pdf
- June 21, 2014
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Taiwan
(PAT NO: I399338).
- April 22, 2014
- Research of ‘‘Therapeutic efficacy of infusing 1ppm molecular hydrogen-resolved saline on rheumatoid
arthritis ’’ employing the nondestructive hydrogen adding method will be presented at the 58th Annual Assembly
and Scientific Meeting of the Japan College of Rheumatology held on April 25, 2014, as a result of
collaborative research by our company, Haradoi Hospital and Midorino Clinic.
- April 4, 2014
- "Hydrogen adding equipment for living organism applicable fluid" was granted a patent in Hong Kong (PAT NO:
HK1172006).
- March 20, 2014
- "Apparatus for supplying high-concentration hydrogen gas for living organism" was granted a patent in Japan
(PAT NO: 5502973).
- March 11, 2014
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Taiwan
(PAT NO: I429583).
- February 20, 2014
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Australia
(PAT NO: 2011277514).
- February 3, 2014
- Research of ‘‘Therapeutic intervention with molecular hydrogen for bronchopulmonary dysplasia (BPD) in
neonates’’ employing the super-saturated hydrogen generating apparatus was presented at the 4th Symposium of
Medical Molecular Hydrogen held on February 1 and 2, 2014, as a result of collaborative research by our
company and Nagoya University of Graduate School of Medicine.
- February 3, 2014
- Research of ‘‘Anti-inflammatory effects of water containing a high concentration (5-7 ppm) of molecular
hydrogen on rheumatoid arthritis (RA)’’ employing the super-saturated hydrogen generating apparatus and
nondestructive hydrogen adding method was presented at the 4th Symposium of Medical Molecular Hydrogen held on
February 1 and 2, 2014, as a result of collaborative research by our company and Haradoi Hospital.
- February 3, 2014
- Research of ‘‘Hydrogen-rich preservation solutions improve cell viability of osteochondral tissues after
cold preservation’’ employing the nondestructive hydrogen adding method was presented at the 4th Symposium of
Medical Molecular Hydrogen held on February 1 and 2, 2014, as a result of collaborative research by our
company and Kitasato University Graduate School of Medical Science.
- February 3, 2014
- Research of ‘‘Combination treatment with H2 water and H2 gas for hepatocellular carcinoma in a mouse model
of non-alcoholic steatohepatitis’’ employing the super-saturated hydrogen generating apparatus was presented
at the 4th Symposium of Medical Molecular Hydrogen held on February 1 and 2, 2014, as a result of
collaborative research by our company and Chubu University.
- February 3, 2014
- Research of ‘‘Effects of hydrogen-rich water on palatal wound healing in rats’’ employing the
super-saturated hydrogen generating apparatus was presented by The University of Tokushima Graduate School, at
the 4th Symposium of Medical Molecular Hydrogen held on February 1 and 2, 2014.
- January 30, 2014
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Hong Kong
(PAT NO: HK1173427).
- January 30, 2014
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Taiwan
(PAT NO: HK1172602).
- January 20, 2014
- Research of ‘‘Subcutaneous administration with hydrogen-included transfusion suppresses the progression of
feline chronic kidney disease (CKD)’’ employing the non-destructive hydrogen adding method will be presented
at the 4th Symposium of Medical Molecular Hydrogen held on February 1 and 2, 2014, as a result of
collaborative research by our company and Sakata Medical and Nursing Care Animal Clinic Co., Ltd.
- January 15, 2014
- "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE
SAME" was granted a patent in Singapore (PAT NO: 174176).
- November 7, 2013
- Research of ‘‘Efficacy of molecular hydrogen- included preservation water on ischemia-reperfusion injury in
small intestine transplantation of swine’’ employing the non-destructive hydrogen adding method will be
presented at the 40th Congress of Japan Society for Organ Preservation and Medical Biology held on
November 9 and 10, 2013, as a result of collaborative research by our company and National Center for Child
Health and Development.
- November 5, 2013
- "Instrument for nondestructively producing high-concentration hydrogen solution" was granted a patent in US
(PAT NO: 8574503B2).
- November 5, 2013
- Research of ‘‘Effects of intravenous administration of hydrogen-included saline on oxidative stress in
thoroughbred horses following very intense exercise’’ employing the non-destructive hydrogen adding method
will be presented at the 26 th Annual Meeting of Japanese Society of Equine Science held on
December 2 and 3, 2013, as a result of collaborative research by our company, Yamazaki Horse Clinic, Miho
Training Center in Japan Racing Association, Ecomo International Co., Ltd., and Yamanashi University.
- Ocotober 30, 2013
- "Hydrogen adding equipment for living organism applicable fluid" was granted a patent in China (PAT NO:
ZL201180007759.7).
- October 24, 2013
- "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE
SAME" was granted a patent in Indonesia (PAT NO: ID P 000 034818).
- September 24, 2013
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Korea (PAT
NO: 10-1313358).
- August 14, 2013
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in China (PAT
NO: ZL20118001790.8).
- July 29, 2013
- "Instrument for nondestructively producing high-concentration hydrogen solution" was granted a patent in
Korea (PAT NO: 10-1292859).
- July 8, 2013
- A document titled ‘‘Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a
novel approach to suppress oxidative stress in the peritoneal cavity’’ employing the nondestructive hydrogen
adding method is disclosed in the journal of Medical Gas Research, as a result of collaborative research by
our company and Fukushima Medical University.
→ Link: http://www.medicalgasresearch.com/content/pdf/2045-9912-3-14.pdf
- July 8, 2013
- A document titled ‘‘Safety of intravenous administration of hydrogen-enriched fluid in patients with acute
cerebral ischemia: initial clinical studies’’ employing the nondestructive hydrogen adding method is disclosed
in the journal of Medical Gas Research, as a result of collaborative research by our company and National
Defense Medical College.
→ Link: http://www.medicalgasresearch.com/content/pdf/2045-9912-3-13.pdf
- June 21, 2013
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in China (PAT
NO: I399338).
- June 21, 2013
- "Instrument for nondestructively producing high-concentration hydrogen solution" was granted a patent in
China (PAT NO: I399344).
- June 11, 2013
- "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE
SAME" was granted a patent in US (PAT NO: 8460861).
- March 22, 2013
- "Apparatus for supplying high-concentration hydrogen gas for living organism" was granted a patent in Japan
(PAT NO: 5228142).
- March 21, 2013
- "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE
SAME" was granted a patent in Taiwan (PAT NO: 5091364).
- March 21, 2013
- Research of ‘Effects of hydrogen-included water on ischemia-reperfusion injury in small intestine’ employing
the super-saturated hydrogen generating apparatus and nondestructive hydrogen adding method was presented at
the 25th Japanese Society for Small Bowel Transplantation held on March 16, 2013.
- March 21, 2013
- A document titled ‘Pilot study of H(2) therapy in
Parkinson's disease: A randomized double-blind placebo-controlled trial’ employing the super-saturated
hydrogen generating apparatus was disclosed in the journal of Movement Disorders.
- March 15, 2013
- "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE
SAME" was granted a patent in Hong Kong (PAT NO: HK1151455).
- March 8, 2013
- A document titled ‘The final results of controversy in hydrogen water. A real water and an imitation water
obtained from experiment by magazine’ employing the super-saturated hydrogen generating apparatus was
disclosed in the weekly magazine of Shukan Bunshun published on February 28, and it was demonstrated
that concentration of molecular hydrogen using the apparatus is 5.0 ppm and is 5 to 50 times higher than those
of other commercially available hydrogen waters.
- February 27, 2013
- A document titled ‘A novel method of preserving
cardiac grafts using a hydrogen-rich water bath’employing the nondestructive hydrogen adding method is
disclosed in The Journal of Heart and Lung Transplantation.
- February 27, 2013
- Research of ‘Effects of hydrogen-saturated water on monocrotaline-induced pulmonary hypertension in a rat
model’ using the electrolytic cell and an electrolytic water generating apparatus was presented at the 3th
Symposium of Medical Molecular Hydrogen held on February 9, 2013.
- February 27, 2013
- Research of ‘Administration of hydrogen water delays the disease onset of amyotrophic lateral sclerosis in a
mouse model’ using the electrolytic cell and an electrolytic water generating apparatus was presented at the
3th Symposium of Medical Molecular Hydrogen held on February 9, 2013.
- February 27, 2013
- Research of ‘Examination of hydrogen concentrations in expiratory gas when ingested with hydrogen water and
non-digestible saccharides’ using the electrolytic cell and an electrolytic water generating apparatus was
presented at the 3th Symposium of Medical Molecular Hydrogen held on February 10, 2013.
- January 31, 2013
- "Selective hydrogen adding equpment for living organism applicable fluid" was granted a patent in Korea (PAT
NO: 10-1230792).
- January 31, 2013
- "Hydrogen adding equipment for living organism applicable fluid" was granted a patent in Korea (PAT NO:
10-1230783).
- January 23, 2013
- Research of ‘Pharmacokinetic analyses by measurement of tissue concentrations in rats treated with molecular
hydrogen in various administration routes ’ using the super-saturated hydrogen generating apparatus and
biological hydrogen gas supplying apparatus will be presented at the 3th Symposium of Medical Molecular
Hydrogen held on February 10, 2013.
- January 23, 2013
- Research of ‘Randomized and double blind controlled trial with hydrogen water for Parkinson’s patients’
using the electrolytic cell and an electrolytic water generating apparatus will be presented at the 3th
Symposium of Medical Molecular Hydrogen held on February 10, 2013.
- December 2, 2012
- Research of 'Effect of foot bath treatment with hydrogen rich water on legs lesion and ulcer in refractory
arteriosclerosis obliterans' using the nondestructive hydrogen adding method will be presented at the 87th
Scientific Meeting of the Fukushima Renal Failure Association.
- November 16, 2012
- Research of 'Development of organ preservation solution by nondestructive hydrogen adding treatment in small
bowel transplantation' using the nondestructive hydrogen adding method and super-saturated hydrogen generating
apparatus will be presented at the 39th Japan Society for Organ Preservation and Medical Biology.
- November 10, 2012
- "PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE
SAME" was granted a patent in Russia (PAT NO: 2465910).
- October 20, 2012
- The website has been revised. A ‘What is molecular hydrogen?’ page has been newly
added.
- October 12, 2012
- Research of ‘Randomized and double blind controlled trial with hydrogen water for Parkinson’s patients’
using electrolytic cell and an electrolytic water generating apparatus will be presented at the 6th
Annual Meeting of the Movement Disorder Society of Japan.
- October 5, 2012
- "Apparatus for supplying high-concentration hydrogen gas for living organism" was granted a patent in Japan
(PAT NO: 5100911).
- October 02, 2012
- A document titled “Consumption of
water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in
patients with rheumatoid arthritis: an open-label pilot study” employing the super-saturated hydrogen
generating apparatus is disclosed in Medical Gas Research.
- September 22, 2012
- Research of ‘Clinical trial of dialysis water contained with molecular hydrogen’ using the nondestructive
hydrogen adding method will be presented at the 18th Annual Meeting of the Japanese Society for
Peritoneal Dialysis.
- September 21, 2012
- "Apparatus for supplying hydrogen gas for living organism" was granted a patent in Japan (PAT NO: 5091364).
- September 09, 2012
- Research of ‘Randomized and double blind controlled trial with hydrogen water for Parkinson’s patients’
using electrolytic cell and an electrolytic water generating apparatus will be presented at the
16th Eurropean Federation
of Neurogical Societies.
- August 31, 2012
- ‘Research on measurement of hydrogen concentration for each internal organ through oral ingestion of
hydrogen-rich water’ employing the super-saturated hydrogen generating apparatus will be presented at the
59th Convention of the Japanese Society for Food Science and Technology.
